In 2003, Dr. Brian developed the Holcomb C3-R®Crosslinking System - the out patient, 30 minute, NON-invasive procedure to have higher safety for patients than CXL where the epithelium is disrupted. Holcomb C3-R® Crosslinking System is SAVING people from significant pain and induced blurred vision during the first month that happens when the epithelium is removed. Dr. Brian invented the "epi-on" or transepithelial crosslinking technique in 2003 because he saw the pain and problems people were having from cross linking with removal of epithelium.
During Holcomb C3-R®, our proprietary Crosslinking Solution (containing riboflavin and other compounds) is applied to the cornea, which is then activated by a special light.
As it was developed in 2003, Holcomb C3-R® Crosslinking System retains the longest track record of ALL of cross-linking procedures in the U.S., Canada, South America & Latin America, Europe (with the exception of Germany), and Asia. With the Holcomb C3-R® Crosslinking System you can rest as easy as a baby wrapped in a warm blanket that you are getting “the real thing” that was developed by modern crosslinking guru, Dr. Brian.
In addition, Dr. Brian invented a special process where both of your eyes can be treated at the same time. With the Holcomb C3-R® Crosslinking System you won't have to return on a different day for the second eye to be treated (which as you can imagine is very inconvenient to your daily routine).
The Holcomb C3-R® Crosslinking System is special and proprietary - it is only available at our office - it is not available anywhere else.
Dr. Brian developed a proprietary Crosslinking Solution that is one of several keys to its success. Holcomb C3-R® is protected by the United States Patent and Trademark Office. For more details, please click on link in right column, "How Holcomb C3-R Was Developed".
Removing the epithelium (as done with CXL) creates a painful recovery and significantly increases risk of infection, corneal haze, scarring, and corneal nerve trauma requiring 6 months to recover. The non-invasive Holcomb C3-R®allows patients to return to their normal routine the very next day!
Our studies and studies of other eye doctors in outside countries have shown patient results are not signficantly different with crosslinking with removal of epithelium vs. leaving epithelium undisturbed in its place. Therefore, it is not necessary to scrape off the epithelium for crosslinking and is safer without scraping off your epithelium.
Risks of Holcomb C3-R®
The risk of the Holcomb C3-R® Crosslinking System is mild irritation for a couple of days. And most people NEVER even experience that. That's it.
Risks of Epi-off CXL
The complication rate of "epi-off" (removal of epithelium) CXL crosslinking procedure was recently reported to be high at 11%.. Complications of CXL include:
1) severe pain
2) corneal infection and ulceration
3) corneal haze
4) delayed epithelial healing
5) worse, more blurry vision
6) delay in corneal nerve regeneration
7) permanent corneal scarring
8) induced visual distortions
9) peripheral flap melting in patients who had previous LASIK and flap dislodgement
10) cornea swelling that never goes away
11) damage to iris causing change in eye color
12) extended light sensitivity
13) cornea perforation (hole was accidentally made through entire thickness of cornea)
The above CXL complications have NEVER occured with the Holcomb C3-R®Crosslinking System.
Patients Explain that Dr. Brian’s Holcomb C3-R was Significantly Easier (No Pain) with 1-Day Recovery vs. Very Painful and Long Recovery CXL
The retreatment rate with the Holcomb C3-R® Crosslinking System is 0.7% (less than 1%) which is significantly less than Epi-off CXL which have retreatment rates as high as 7%. Why the much lower retreatment rate with Holcomb C3-R®? There are two powerful reasons:
1) Dr. Brian customizes the energy level he uses for each patient, so he customizes the amount of crosslinking for your eyes. He is the ONLY doctor who can do this. OTHER DEVICES THAT DOCTORS USE ONLY HAVE A SINGLE (LOW) ENERGY SETTING THAT THEY CANNOT CHANGE. As a result, a number of people who have CXL elsewhere unfortunately are “under-crosslinked” which is the reason the rate of Keratoconus progression is SIGNIFICANTLY higher with CXL than Holcomb C3-R®. Holcomb C3-R® gives you “peace-of-mind.”
2) Holcomb C3-R® Crosslinking System covers the greatest corneal area for crosslinking - it covers 157% more surface area of the cornea compared to other techniques such as CXL. This allows for a more complete area of treatment which is important since Keratoconus extends into the periphery of your cornea . We make sure we treat your central cornea areas as well as the far periphery of your corneas with the Holcomb C3-R® Crosslinking System.
This is the reason that 99.3% of people are stabilized with just a single treatment.
3) Some doctors are now "trying" epi-on crosslinking. Do not be fooled. 1) They are using solutions that do NOT have the long track of the proprietary solution used in Holcomb C3-R and 2) Those epi-on patients are being "under-crosslinked" because the device these doctors use has ONLY a LOW energy setting. Epi-on crosslinking MUST be done with higher energy levels to produce more crosslinking. Dr. Brian’s Holcomb C3-R, invented in 2003, does that and THAT is part of the reason the success rate of Holcomb C3-R is 99.3%.
Other Reasons for You to Have Holcomb C3-R®
Patients with very thin corneas cannot be treated with CXL. Even if you have an extremely thin corneas, the good news is you can still be treated with Holcomb C3-R® to strengthen your corneas and help prevent you from needing a cornea transplant.
The non-surgical Holcomb C3-R® Crosslinking System is a routine part of our practice and has been so for over 10 years. Since Holcomb C3-R® is NOT in a study - our patients are not required to have the multiple "back and forth" office visits which can be quite time-consuming and disruptive to one's school or work schedule.
Dr. Brian discovered that different degrees of Keratoconus require different amounts of crosslinking. As a result, another proprietary feature of Holcomb C3-R® Crosslinking System is that he customizes the energy level (amount of crosslinking) for each eye of each patient. Dr. Brian is the only doctor in the world who does this with crosslinking.
With Holcomb C3-R® Crosslinking System you can be confident in receiving the optimized level of crosslinking treatment for each of your eyes (vs. the "one size fits all" approach of same energy level for all eyes of all patients with all the other crosslinking techniques including CXL).
The Holcomb C3-R® Crosslinking System can also be combined with Intacs® to flatten the keratoconus cone even more than with Intacs alone. We routinely perform these both procedures on the same day. In these cases, the Holcomb C3-R® Crosslinking System can stabilize keratoconus from getting worse as well as help the Intacs® reverse part of the keratoconus steepening that had already occurred up to the time of the treatment. The combination of same-day Intacs and the Holcomb C3-R® Crosslinking System can give you the ideal results of improved vision AND stability.
Some patients take a "wait and see" approach with Keratoconus. The risk of waiting is that as the cornea continues to bulge out and get worse, the back layer of the cornea can rip open - like someone wearing way too tight pants who sits down and the pants split wide open down the middle seam. When this happens to the progressively bulging cornea, the internal eye liquid rushes in and swells up the cornea the same way a dry sponge soaks up water and becomes very thick.
These photos below show a cornea swollen up like a soppy, wet sponge after it split open. If this happens to you, it will take 3-6 months of non-usable vision until this fluid goes away. When it eventually does, the cornea will have a lot of new scarring and vision will be permanently worse compared to before it ripped open. The good news is that this devastating damage can easily be prevented with the 30-minute, non-invasive, 1-day recovery Holcomb C3-R® - it will give you important peace-of-mind.
You Might be Thinking, "I'm doing fine with my contact lenses, so I have nothing to worry about."
You don't have to worry as much as someone suffering from contact lens issues, BUT YOU STILL HAVE TO WORRY.
Keratoconus is unpredictable and progressive. "It has a mind of its own" since it doesn't follow any rules. Holcomb C3-R® would be recommended at a minimal to strengthen your cornea and not to worry about future vision loss. It is like an "insurance policy for your eyes". Thousands of good people like yourself now sleep as sound as a baby wrapped in a warm blanket after having Holcomb C3-R®.
The Problem with taking a "Wait and See" Approach
This below case of progression occurred in a young woman, but could have been prevented. After consultation with Dr. Brian, she saw another eye doctor in Los Angeles who was uninformed and advised her not to have Holcomb C3-R. The result: significant vision loss from delay of treatment for over 1 year. She came back for Holcomb C3-R which stopped the progression and further vision loss. Unfortunately she won't regain the vision she lost during the one year of delay.
of Years of Stability - This is a Typical Result
Dr. Brian is credited as the first doctor in the world (except Germany) to use corneal crosslinking treatments for keratoconus as well as being the first doctor in the world to combine this treatment with Intacs®. As the inventor of transepithelial Holcomb C3-R® Crosslinking in 2003 - Dr. Brian has the longest crosslinking track record of any doctor in the United States, Canada, Asia, Latin America & South America, and Europe (except for Germany).
People who want the best possible treatment for their eyes choose Dr. Brian. With the Holcomb C3-R® Crosslinking System you can rest assured that you'll be receiving the crosslinking procedure with the longest track record in the world (except for Germany).
Dr. Brian is considered the "Guru of Modern Crosslinking" because of his extensive experience and expertise. Would you trust your precious eyes and the future of your vision to someone who just learned how to do the procedure?
Patients come to us from all over the United States and from other countries.
Some people you like the most in your life may say to you, "Why would you fly out to Beverly Hills?" in the guise of helping you. Unfortunately they don't know the facts of how Keratoconus is affecting or threatening to affect your life. They have no idea what it's like to 'walk in your shoes' because having Keratoconus is like being a stranger in an unfriendly, strange land.
The Holcomb C3-R® Crosslinking System is the only crosslinking procedure with a Gold Medal behind it. The U.S. Bobsled Team effectively endorsed the procedure when they paid 100% of the fee for U.S. Bobsledder Steven Holcomb to have it to save his eyesight - the procedure now bears his name in honor of what Steven accomplished after overcoming his Keratoconus.
Finally, you can overcome your Keratoconus as well.
CHART REVIEW AND CONSULTATION FOR
Many out-of-town patients would like Dr. Brian to do a complimentary review of their medical records and make a preliminary determination of candidacy. This is useful before planning an easy, 3-day trip to Beverly Hills.
No matter where you live, you essentially are just in "our backyard". You are just like so many people who all the time fly or drive to see Dr. Brian.
Some people’s friends ask them, “Why are you thinking of travelling to Beverly Hills for your Keratoconus treatments?” Although well-meaning, friends and family have no idea what it’s like to live with Keratoconus. People usually respond back to friends and family with, “I deserve the BEST and I want to go to the BEST doctor who has the MOST experience, who invented these procedures. I only have two eyes and I want the best for them!”
A records review is easy and the first step to better vision. Here’s how to submit them to Dr. Brian:
These are the three easy steps:
Keratoconus Record Review
Or you can scan your records and email them to
Nationally Honored at the 2010 Vision Awards
Dr. Brian and Steven Holcomb were honored at the 2010 Vision Awards for their historic accomplishments with Holcomb C3-R® that led to a Gold Medal in Vancouver during the 2010 4-man bobsled event. Dr. Brian received the Jules Stein Living Tribute Award for inventing Holcomb C3-R® and Steven received the Athlete of Vision Award for his Gold Medal. Many celebrities were on hand including Will.i.am of the Black Eyed Peas, astronaut Buzz Aldrin, comedienne Lilly Tomlin, cosmetic dentist Dr. Bill Dorfman, and actor Billy Bob Thornton among many others.
- Copyright© Advanced Vision Education, LLC., 2014