World Keratoconus Treatment Authority
Inventor of 1st Non-Invasive Cornea Collagen Crosslinking (since 2003)
Intacs® treatment for Keratoconus • Holcomb C3-R® treatment to strengthen the cornea
CK for astigmatism reduction
Fixing Keratoconus since 1999!
  Brian S. Boxer Wachler, MD 465 N. Roxbury Drive, Suite 902 Beverly Hills, CA 90210 - Phone: 310.594.5210   

Holcomb C3-R®
Proprietary, Non-Invasive, 1-Day Recovery Corneal Collagen Crosslinking

Holcomb C3-R® Crosslinking gives you
“Peace-of-Mind” since it has THE LONGEST TRACK RECORD in the United States vs. ALL other types of crosslinking


  Keratoconus Treatments Saved Steven Holcomb’s Vision

April 9, 2010 - Gold Medalist Bobsled driver Steven Holcomb and World Keratoconus Expert Dr. Brian Boxer Wachler appeared on Dr. Phil’s The Doctors daytime television show, Dr. Brian made the announcement of the name modification of “C3-R” to “Holcomb C3-R” to honor Steven Holcomb.  This was the first time ever in history that a disease treatment was named after a Gold Medal athlete. Click here to watch the naming of Holcomb C3-R® on The Doctors

Keratoconus has increased in frequency over the years.  Keratoconus now occurs 1 in 500 people vs 1 in 2000 in the past (that's a 400% greater frequency now). 

Can you relate?

  • Is your night vision poor?
  • Is it getting harder to read now?
  • Is your vision getting worse?
  • Are you worried about needing a cornea transplant in the future?
  • Were you told by your eye doctor that hard contacts are only option?
  • Were you told by your eye doctor to wait until it gets bad enough to then have a cornea transplant?
  • Are you relying on "one good eye"?

If you answered YES to any of the above, then Keratoconus is significantly affecting your life. 

NFL Network Broadcaster Amber Theoharis Discusses Her Life-Changing Keratoconus Treatments

Frustrated with Keratoconus

If your doctor NEVER mentioned the non-invasive Holcomb C3-R® & Intacs® to you, then you are just as frustrated as we are. 

In 2003, Dr. Brian invented Holcomb C3-R®, the first non-invasive corneal crosslinking procedure for Keratoconus which has the longest track record of ANY form of crosslinking in the world (except Germany).

Many cornea transplant surgeons (whose practice is based on performing invasive cornea transplants) don't want you to know about Holcomb C3-R® since it can PREVENT you from needing a cornea transplant.

For over a fifteen years, Dr. Brian has been educating eye doctors around the world by speaking at scientific meetings and presenting his results of these procedures that he pioneered since 1999. He's published articles in the medical literature and ophthalmology and optometry trade journals.  He's the author of THE book on Keratoconus, Modern Management of Keratoconus.  

Dr. Brian has been the expert on numerous national television (Good Morning America, Today Show, NBC Nightly News, EXTRA, Dr. Drew's LifeChangers to name just a few) and radio shows (NPR, Voice of America, etc) discussing his proprietary modern treatments for Keratoconus that can improve vision and save people from cornea transplants. 

If you are worried about needing a cornea transplant in the future, then continue reading.

And there was the worldwide tsunami of media attention after our Keratoconus patient Steven Holcomb won Gold in 2010 at Vancouver Olympics and double Bronze medals at the 2014 Sochi Olympics.  Before he won these Olympic medals, Steven had to give up being an athlete.  Steven tells how demoralized he was after 12 other eye doctor "specialists" told him his only option was a cornea transplant. His coaches and United States Olympic Team found Dr. Brian and, well, you know the rest of the story.


Is Your Doctor "Behind the Times"?

So if your doctor never heard of Holcomb C3-R®, Intacs®, and CK, then frankly your doctor is likely not keeping up with the Keratoconus field. Even worse - most cornea transplant surgeons don't want you to know about Holcomb C3-R® because their livelihood depends on doing cornea transplants.  It's the unfortunate truth. 

But the good news for you is that YOU did your research and you are here now and discovered these revolutionary treatments that can improve your vision and save you from needing a cornea transplant.

These minimally involved ways can treat your Keratoconus and stop it's progression as it has for many, many thousands of people who flew here for Dr. Brian's gifted hands to help them. This creates tremendous peace-of-mind for people to know their Keratoconus is stable and won't likely progress anymore.  Wouldn't it be wonderful to never stay awake at night stressing about needing a cornea transplant?

Thousands and thousands of Keratoconus patients have already found the solution in a non-invasive process: Holcomb C3-R® Crosslinking System. 

Keratoconus Treatments Saved Steven Holcomb’s Vision

After Holcomb C3-R® and Intacs, one teenager from Arizona was able to become a straight-A student and help his school win their conference basketball championship. Click here to read his letter of gratitude and see his photos and trophy.


Why Travel to see Dr. Brian?

You might be thinking, "Why would someone fly to see Dr. Brian in Beverly Hills?"Answer: 25-30 good people just like you EVERY MONTH travel to see TRUSTED Dr. Brian to treat them and improve their vision, and prevent them from needing a cornea transplant in the future. 

Watch Patients Discuss Keratoconus
Treatment with Dr. Brian

Sure you'll be able to find someone near you so can try to treat you (many surgeons will happily jump at the chance to do procedures especially since Obamacare is affecting their practices), but the reason that 25-30 people every month hop on a plane for the easy 3-day trip is because they want to be treated by the doctor who INVENTED these procedures, who has the longest track record in the world.  On a weekly basis people arrive in our office from out-of-town.  They come from all over the United States (West Coast, Midwest, East Coast, and the South) and from other countries such as Canada, Europe, Asia, South America, Africa, and as far away as Australia.  Every week, people come.  Week after week. Year after year. Now decade after decade. 

Dr. Brian is recognized as a keratoconus specialist and as well as the "Guru of Modern Crosslinking." Good people like yourself, who have keratoconus signs and want to undergo treatment, routinely travel from all parts of the United States, Canada, and outside countries because he developed Holcomb C3-R® Crosslinking System in 2003 which strengthens the compromised cornea that occurs with keratoconus (see Presentation and Research Articles link). This is accomplished by increasing corneal collagen crosslinking, which are the natural "structural anchors" within your cornea. And best of all: this is done WITHOUT surgery with Dr. Brian's advanced technique. The anchors prevent your cornea from further bulging and becoming more distorted (which is the cause of keratoconus). The only place to have the Holcomb C3-R® Crosslinking System is at the Boxer Wachler Vision Institute in Beverly Hills, California.


Keratoconus Keratoconus
The images above show the parallel corneal fibers between the black lines and the crosslinks (red) which increase after Holcomb C3-R®.



Holcomb C3-R® Keratoconus Treatment


In 2003, Dr. Brian developed the Holcomb C3-R®Crosslinking System - the out patient, 30 minute, NON-invasive procedure to have higher safety for patients than CXL where the epithelium is disrupted. Holcomb C3-R®  Crosslinking System is SAVING people from significant pain and induced blurred vision during the first month that happens when the epithelium is removed Dr. Brian invented the "epi-on" or transepithelial crosslinking technique in 2003 because he saw the pain and problems people were having from cross linking with removal of epithelium.

During Holcomb C3-R®, our proprietary Crosslinking Solution (containing riboflavin and other compounds) is applied to the cornea, which is then activated by a special light.


Please watch this video

explaining Holcomb C3-R®



As it was developed in 2003, Holcomb C3-R® Crosslinking System retains the longest track record of ALL of cross-linking procedures in the U.S., Canada, South America & Latin America, Europe (with the exception of Germany), and Asia.  With the Holcomb C3-R® Crosslinking System you can rest as easy as a baby wrapped in a warm blanket that you are getting “the real thing” that was developed by modern crosslinking guru, Dr. Brian.

In addition, Dr. Brian invented a special process where both of your eyes can be treated at the same time.  With the Holcomb C3-R® Crosslinking System you won't have to return on a different day for the second eye to be treated (which as you can imagine is very inconvenient to your daily routine).Keratoconus Webinar

The Holcomb C3-R® Crosslinking System is special and proprietary - it is only available at our office - it is not available anywhere else.

Dr. Brian developed a proprietary Crosslinking Solution that is one of several keys to its success.  Holcomb C3-R® is protected by the United States Patent and Trademark Office. For more details, please click on link in right column, "How Holcomb C3-R Was Developed".


Holcomb C3-R® (cornea collagen crosslinking) – Keratoconus cornea stabilizationRemoving the epithelium (as done with CXL) creates a painful recovery and significantly increases risk of infection, corneal haze, scarring, and corneal nerve trauma requiring 6  months to recover.  The non-invasive Holcomb C3-R®allows patients to return to their normal routine the very next day!

Our studies and studies of other eye doctors in outside countries have shown patient results are not signficantly different with crosslinking with removal of epithelium vs. leaving epithelium undisturbed in its place.  Therefore, it is not necessary to scrape off the epithelium for crosslinking and is safer without scraping off your epithelium.


Risks of Holcomb C3-R®

The risk of the Holcomb C3-R® Crosslinking System is mild irritation for a couple of days.  And most people NEVER even experience that.  That's it.

Risks of Epi-off CXL

The complication rate of "epi-off" (removal of epithelium) CXL crosslinking procedure was recently reported to be high at 11%..  Complications of CXL include:    

1) severe pain

2) corneal infection and ulceration

3) corneal haze

4) delayed epithelial healing

5) worse, more blurry vision

6) delay in corneal nerve regeneration

7) permanent corneal scarring

8) induced visual distortions

9) peripheral flap melting in patients who had previous LASIK and flap dislodgement

10) cornea swelling that never goes away

11) damage to iris causing change in eye color

12) extended light sensitivity

13) cornea perforation (hole was accidentally made through entire thickness of cornea)

The above CXL complications have NEVER occured with the Holcomb C3-R®Crosslinking System.

Patients Explain that Dr. Brian’s Holcomb C3-R was Significantly Easier (No Pain) with 1-Day Recovery vs. Very Painful and Long Recovery CXL


Scott had CXL in the UK one eye before Holcomb C3-R on the other with Dr. Brian.
Irfan compares CXL (painful) in one eye to Holcomb C3-R (no pain) in the other eye.

Jordan had CXL in England and Holcomb C3-R and had vast differences in experiences.
Dan had CXL on one eye and had
Holcomb C3-R in the other.

The retreatment rate with the Holcomb C3-R® Crosslinking System is 0.7% (less than 1%) which is significantly less than Epi-off CXL which have retreatment rates as high as 7%.  Why the much lower retreatment rate with Holcomb C3-R® There are two powerful reasons:

1) Dr. Brian customizes the energy level he uses for each patient, so he customizes the amount of crosslinking for your eyes. He is the ONLY doctor who can do this. OTHER DEVICES THAT DOCTORS USE ONLY HAVE A SINGLE (LOW) ENERGY SETTING THAT THEY CANNOT CHANGE. As a result, a number of people who have CXL elsewhere unfortunately are “under-crosslinked” which is the reason the rate of Keratoconus progression is SIGNIFICANTLY higher with CXL than Holcomb C3-R®. Holcomb C3-R® gives you “peace-of-mind.”

2) Holcomb C3-R® Crosslinking System covers the greatest corneal area for crosslinking - it covers 157% more surface area of the cornea compared to other techniques such as CXL.  This allows for a more complete area of treatment which is important since Keratoconus extends into the periphery of your cornea .  We make sure we treat your central cornea areas as well as the far periphery of your corneas with the Holcomb C3-R® Crosslinking System.

This is the reason that 99.3% of people are stabilized with just a single treatment.

3) Some doctors are now "trying" epi-on crosslinking.  Do not be fooled. 1) They are using solutions that do NOT have the long track of the proprietary solution used in Holcomb C3-R and 2) Those epi-on patients are being "under-crosslinked" because the device these doctors use has ONLY a LOW energy setting. Epi-on crosslinking MUST be done with higher energy levels to produce more crosslinking. Dr. Brian’s Holcomb C3-R, invented in 2003, does that and THAT is part of the reason the success rate of Holcomb C3-R is 99.3%.


Dr. Brian was selected to give a prestigious TEDx talk about how he fought on behalf of patients diagnosed with Keratoconus (a degenerative eye disease), to pioneer the Holcomb C3-R® procedure to save them from cornea transplants.

He described the emotional battle and what he had to overcome to make Holcomb C3-R® the widely accepted procedure that it is today for patients with Keratoconus.

To watch a video of Dr. Brian's TEDx talk, click on the picture to the right.

Please click on photo to watch Dr. Brian’s
incredible TEDx talk.


Other Reasons for You to Have Holcomb C3-R®

Patients with very thin corneas cannot be treated with CXL. Even if you have an extremely thin corneas, the good news is you can still be treated with Holcomb C3-R® to strengthen your corneas and help prevent you from needing a cornea transplant.

The non-surgical Holcomb C3-R® Crosslinking System is a routine part of our practice and has been so for over 10 years.  Since Holcomb C3-R® is NOT in a study - our patients are not required to have the multiple "back and forth" office visits which can be quite time-consuming and disruptive to one's school or work schedule. 

Dr. Brian discovered that different degrees of Keratoconus require different amounts of crosslinking.  As a result, another proprietary feature of Holcomb C3-R® Crosslinking System is that he customizes the energy level (amount of crosslinking) for each eye of each patient. Dr. Brian is the only doctor in the world who does this with crosslinking.

With Holcomb C3-R® Crosslinking System you can be confident in receiving the optimized level of crosslinking treatment for each of your eyes (vs. the "one size fits all" approach of same energy level for all eyes of all patients with all the other crosslinking techniques including CXL).

The Holcomb C3-R® Crosslinking System can also be combined with Intacs® to flatten the keratoconus cone even more than with Intacs alone. We routinely perform these both procedures on the same day.  In these cases, the Holcomb C3-R® Crosslinking System can stabilize keratoconus from getting worse as well as help the Intacs® reverse part of the keratoconus steepening that had already occurred up to the time of the treatment.  The combination of same-day Intacs and the Holcomb C3-R® Crosslinking System can give you the ideal results of improved vision AND stability.





The figure above demonstrates almost 10 diopters of corneal flattening in one patient before (left) after this combined treatment (right).


Some patients take a "wait and see" approach with Keratoconus. The risk of waiting is that as the cornea continues to bulge out and get worse, the back layer of the cornea can rip open - like someone wearing way too tight pants who sits down and the pants split wide open down the middle seam. When this happens to the progressively bulging cornea, the internal eye liquid rushes in and swells up the cornea the same way a dry sponge soaks up water and becomes very thick.

These photos below show a cornea swollen up like a soppy, wet sponge after it split open. If this happens to you, it will take 3-6 months of non-usable vision until this fluid goes away. When it eventually does, the cornea will have a lot of new scarring and vision will be permanently worse compared to before it ripped open. The good news is that this devastating damage can easily be prevented with the 30-minute, non-invasive, 1-day recovery Holcomb C3-R® - it will give you important peace-of-mind.




You Might be Thinking, "I'm doing fine with my contact lenses, so I have nothing to worry about."

You don't have to worry as much as someone suffering from contact lens issues, BUT YOU STILL HAVE TO WORRY.

Keratoconus is unpredictable and progressive. "It has a mind of its own" since it doesn't follow any rules. Holcomb C3-R® would be recommended at a minimal to strengthen your cornea and not to worry about future vision loss. It is like an "insurance policy for your eyes". Thousands of good people like yourself now sleep as sound as a baby wrapped in a warm blanket after having Holcomb C3-R®.

The Problem with taking a "Wait and See" Approach

This below case of progression occurred in a young woman, but could have been prevented.  After consultation with Dr. Brian, she saw another eye doctor in Los Angeles who was uninformed and advised her not to have Holcomb C3-R. The result: significant vision loss from delay of treatment for over 1 year. She came back for Holcomb C3-R which stopped the progression and further vision loss.  Unfortunately she won't regain the vision she lost during the one year of delay.


Keratoconus Keratoconus

Keratoconus Keratoconus

Natural progression of keratoconus in a patient’s eyes over 1.5 years. Notice the dramatic lower cone steepening (red) and increased astigmatism over this short period of time.  Holcomb C3-R® can halt this progression and prevent these progressive distortions in vision. Note: not all keratoconus progresses this rapidly.



Example of Years of Stability -   This is a Typical Result


Dr. Brian is credited as the first doctor in the world (except Germany) to use corneal crosslinking treatments for keratoconus as well as being the first doctor in the world to combine this treatment with Intacs®.  As the inventor of transepithelial Holcomb C3-R® Crosslinking in 2003 - Dr. Brian has the longest crosslinking track record of any doctor in the United States, Canada, Asia, Latin America & South America, and Europe (except for Germany). 

People who want the best possible treatment for their eyes choose Dr. Brian. With the Holcomb C3-R® Crosslinking System you can rest assured that you'll be receiving the crosslinking procedure with the longest track record in the world (except for Germany). 

Dr. Brian is considered the "Guru of Modern Crosslinking" because of his extensive experience and expertise.  Would you trust your precious eyes and the future of your vision to someone who just learned how to do the procedure?

Patients come to us from all over the United States and from other countries. 

Some people you like the most in your life may say to you, "Why would you fly out to Beverly Hills?" in the guise of helping you.  Unfortunately they don't know the facts of how Keratoconus is affecting or threatening to affect your life.  They have no idea what it's like to 'walk in your shoes' because having Keratoconus is like being a stranger in an unfriendly, strange land.

The Holcomb C3-R® Crosslinking System is the only crosslinking procedure with a Gold Medal behind it.   The U.S. Bobsled Team effectively endorsed the procedure when they paid 100% of the fee for U.S. Bobsledder Steven Holcomb to have it to save his eyesight - the procedure now bears his name in honor of what Steven accomplished after overcoming his Keratoconus. 

Finally, you can overcome your Keratoconus as well.



Many out-of-town patients would like Dr. Brian to do a complimentary review of their medical records and make a preliminary determination of candidacy. This is useful before planning an easy, 3-day trip to Beverly Hills.

No matter where you live, you essentially are just in "our backyard". You are just like so many people who all the time fly or drive to see Dr. Brian.

Some people’s friends ask them, “Why are you thinking of travelling to Beverly Hills for your Keratoconus treatments?” Although well-meaning, friends and family have no idea what it’s like to live with Keratoconus. People usually respond back to friends and family with, “I deserve the BEST and I want to go to the BEST doctor who has the MOST experience, who invented these procedures. I only have two eyes and I want the best for them!”

A records review is easy and the first step to better vision. Here’s how to submit them to Dr. Brian:

These are the three easy steps:

  • Along with your last 2 or 3 eye exams, please be sure to include a color copy of your corneal mapping. Color corneal mapping is a very important tool, along with your exam history, to determine your candidacy. The last 2 years of your total eye history will be used to make this preliminary determination.

  • Inside the envelope, please be sure to include a cover sheet with your name address, phone number and email address and the words, “Keratoconus Record Review”, so that we may optimize communication with you.

  • Enclose with your letter a copy of your records.

    Mail to:
    Boxer Wachler Vision Institute

           Keratoconus Record Review
           465 N. Roxbury Drive, Suite 902
           Beverly Hills, CA 90210

Or you can scan your records and email them to

           Dr. Brian's Keratoconus Specialist will contact you to discuss the review.



Nationally Honored at the 2010 Vision Awards

Dr. Brian and Steven Holcomb were honored at the 2010 Vision Awards for their historic accomplishments with Holcomb C3-R® that led to a Gold Medal in Vancouver during the 2010 4-man bobsled event.  Dr. Brian received the Jules Stein Living Tribute Award for inventing Holcomb C3-R® and Steven received the Athlete of Vision Award for his Gold Medal.  Many celebrities were on hand including of the Black Eyed Peas, astronaut Buzz Aldrin, comedienne Lilly Tomlin, cosmetic dentist Dr. Bill Dorfman, and actor Billy Bob Thornton among many others.


Dr. Brian Boxer-Wachler Keratoconus
Steve Holcomb - Keratoconus
Dr. Brian speaking
Steven Holcomb at the podium
Dr. Brian Boxer-Wachler Keratoconus
Dr. Brian Boxer-Wachler Keratoconus
Dr. Brian before the press
Steven Holcomb with his gold medal and plaque
Buzz Aldrin Dr. Brian Boxer-Wachler Keratoconus
Dr. Bill Dorfman Dr. Brian Boxer-Wachler Keratoconus
  Steve Holcomb - Dr. Brian Boxer-Wachler Keratoconus - Keratoconus
Buzz Aldrin
Dr. Bill Dorfman
Dr. Brian & Steven




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This website is designed to provide general information about vision, vision care and vision correction. It is not intended to provide medical advice. If you suspect that you have a vision problem or a condition that requires attention, consult an eyecare professional for advice on the treatment of your own specific condition and for your own particular needs.



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Brian S. Boxer Wachler, M.D. - 465 N. Roxbury Drive, Suite 902 - Beverly Hills, CA 90210 - 310.860.1900